Introduction to 6-Bromo-2-Naphthol

6-Bromo-2-Naphthol, with the chemical formula C10H7BrO, is an aromatic compound belonging to the class of naphthols. This compound is characterized by a bromine atom attached to the naphthol structure, contributing to its unique reactivity and properties. It is predominantly used in organic synthesis, particularly in the production of dyes, pharmaceuticals, and other specialized chemicals.

Chemical Properties and Synthesis

Chemical Properties

6-Bromo-2-Naphthol (CAS No: 533-60-8) is notable for its stability and reactivity, which make it suitable for various synthetic applications. The key properties of 6-Bromo-2-Naphthol include:

• Molecular Weight: 223.07 g/mol
• Melting Point: 148-152°C
• Solubility: Sparingly soluble in water, but more soluble in organic solvents such as ethanol and acetone.

Synthesis

The synthesis of 6-Bromo-2-Naphthol typically involves the bromination of 2-naphthol. This process is carried out using bromine or other brominating agents under controlled conditions to ensure the selective substitution of the bromine atom at the desired position on the naphthol ring.

Applications of 6-Bromo-2-Naphthol

6-Bromo-2-Naphthol is utilized in various fields of organic synthesis. Some of its primary applications include:

1. Dye Production: It is used as an intermediate in the synthesis of dyes, contributing to the creation of colorants for textiles and other materials.
2. Pharmaceutical Intermediates: 6-Bromo-2-Naphthol serves as a building block in the synthesis of various pharmaceutical compounds, aiding in the development of medications.
3. Chemical Research: Its reactivity and stability make it a valuable reagent in chemical research, facilitating the synthesis of complex organic molecules.

Most Selling Products

• 2-Bromoethanol
• Bromoacetonitrile
• 2-Bromophenol
• Methyl Triflate

Health Risks and Safety Precautions

Health Risks

6-Bromo-2-Naphthol poses several health risks, particularly through inhalation, ingestion, or skin contact. Exposure can lead to irritation of the eyes, skin, and respiratory system, causing symptoms such as coughing, difficulty breathing, and skin burns. Prolonged or repeated exposure may result in more serious health issues, including potential organ damage.

Safety Measures

To handle 6-Bromo-2-Naphthol safely, it is crucial to implement stringent safety protocols:

1. Personal Protective Equipment (PPE): Wear appropriate PPE, including gloves, safety goggles, and lab coats.
2. Ventilation: Ensure adequate ventilation in the working area, preferably by using a fume hood.
3. Storage: Store 6-Bromo-2-Naphthol in a cool, dry place away from incompatible materials such as strong oxidizers.
4. Handling: Handle with care, avoiding direct contact and inhalation. Always work in a well-ventilated area and take precautions to prevent spills and accidents.

Environmental Impact

6-Bromo-2-Naphthol can be harmful to aquatic life and may cause long-term adverse effects in the aquatic environment. Proper disposal methods should be followed to minimize its environmental impact. Waste containing 6-Bromo-2-Naphthol should be disposed of in accordance with local, state, and federal regulations to ensure environmental safety.

Conclusion

6-Bromo-2-Naphthol is a valuable compound in organic synthesis, offering a wide range of applications in dye production, pharmaceuticals, and research. However, its hazardous nature requires careful handling and adherence to safety protocols to prevent health risks and environmental damage. By understanding its properties, applications, and associated risks, professionals can effectively utilize 6-Bromo-2-Naphthol while maintaining safety and compliance with regulatory standards.